From the 1950s, the momentum was growing in the Space Race to develop spaceflight. A need arose for an international network of tracking stations around the globe to communicate with satellites and crewed space capsules and to control their flight trajectory. On 18 March 1960, the Spanish and US Governments signed an agreement to establish a NASA satellite ground station on Gran Canaria, the first in Spain. The location was chosen because Maspalomas is on the same latitude as Cape Canaveral, with the two locations separated only by the Atlantic Ocean.
The original Maspalomas Station was built by NASA close to the Maspalomas Lighthouse in 1960. It was initially set to provide support for NASA's first human spaceflight mission, the Mercury Program, one of 14 such stations in the Manned Space Flight Network (MSFN) distributed around the globe. It came into operation on 13 September 1961 to support the Mercury-Atlas 4 test flight, and continued to take part in Mercury missions, including John Glenn’s Mercury-Atlas 6 Earth orbit. Subsequently, Maspalomas participated in the ground control network for NASA's crewed flight programme Project Gemini (1965-1966).
The expansion of tourism in the southern part of Grand Canaria threatened the radio quiet zone around Maspalomas station. NASA agreed with INTA and the Spanish Government to move operations to a new, more remote site several kilometres away from the original site. The new ground station retained the name of Maspalomas.
Maspalomas Station continued to provide support for international space missions, including the launch of early communications satellites by Intelsat, who named their third satellite, Intelsat II F-3, Canary Bird after the Canary Islands.